EmbryoGlue in IVF: How It Works and When It Can Help

Supporting embryo implantation For couples undergoing IVF, the time after embryo transfer can be emotionally intense. Even when everything seems to go right, implantation may still not occur. That’s where EmbryoGlue can help: a special transfer medium designed to support the embryo’s ability to implant in the uterus. In this article, we explain how EmbryoGlue works, what science says about its benefits, and whether it might be right for your treatment.

What Is EmbryoGlue?

Not a glue, but a scientifically designed culture medium

Despite its name, EmbryoGlue is not an adhesive. It’s a specially formulated culture medium used during embryo transfer. It mimics the natural environment of the uterus and contains high levels of hyaluronic acid – a molecule naturally found in the uterine lining and thought to support implantation.

Key ingredients in EmbryoGlue:

• Hyaluronic acid – increases embryo adhesion to the endometrium
• Carbohydrates & amino acids – support embryonic cells during transfer
• Electrolytes – optimize the biochemical environment

The embryo is placed in EmbryoGlue immediately before transfer into the uterus.

When Is EmbryoGlue Used?

EmbryoGlue is commonly used during the transfer of blastocysts (embryos cultured to day 5), when the window for implantation is at its most critical.

EmbryoGlue is often considered in the following cases:

• Multiple failed IVF/ICSI cycles despite high-quality embryos
• Suspected or unexplained implantation failure
• Patients seeking to maximize implantation chances
• Frozen embryo transfers

👉 Note: EmbryoGlue is a supportive measure, but it cannot guarantee implantation

How Does EmbryoGlue Work?

The science behind improved implantation

The main active component, hyaluronic acid, increases the “stickiness” of the environment, allowing the embryo to stay in close contact with the uterine lining. This may help promote successful implantation in select patients.

Theoretical benefits include:

• A thicker, more viscous medium mimicking natural uterine conditions
• Improved embryo-endometrium interaction
• Prolonged embryo retention in the optimal implantation zone

What Does the Research Say?

While EmbryoGlue is not part of standard IVF protocols, multiple studies have explored its potential benefits.

A 2015 study by Singh et al. (J Hum Reprod Sci; DOI:10.4103/0974-1208.170398) found a higher implantation and clinical pregnancy rate when EmbryoGlue was used during fresh IVF cycles – especially in patients with previous failed attempts.

Possible advantages based on studies:

• Slight increase in clinical pregnancy rate (around 10–15%)
• No increase in miscarriage risk
• Safe and well tolerated

📌 EmbryoGlue may be particularly helpful for women with two or more failed transfers or unclear implantation issues.

EmbryoGlue Cost: What to Expect

A self-paid option with potential value

EmbryoGlue is considered an add-on treatment and is not covered by statutory health insurance in Germany.

• Average cost: approx. €160 per transfer
• Price includes consultation, preparation, and application
• Private insurers may cover costs on a case-by-case basis – please check in advance

Are There Any Side Effects or Risks?

Generally well tolerated

Because EmbryoGlue contains natural substances found in the body, it’s typically very well tolerated. Rare allergic reactions are possible, but extremely uncommon.

Things to consider:

• No guaranteed pregnancy success
• Additional cost without universal benefit
• Limited data for certain patient groups

At Kinderwunschzentrum Dresden, we provide individual counseling to help you decide whether EmbryoGlue is medically appropriate for your situation.

EmbryoGlue and Implantation – Summary in Numbers

FAQ – Frequently Asked Questions

What is EmbryoGlue?
A culture medium containing hyaluronic acid, designed to enhance embryo adhesion to the uterine lining during IVF.

When is EmbryoGlue used?
Usually during blastocyst transfer or after failed IVF/ICSI attempts.

Does EmbryoGlue guarantee pregnancy?
No – it may increase implantation chances, but does not guarantee success.

Are there any side effects?
Generally none. EmbryoGlue is safe and well tolerated in most cases. Allergic reactions are very uncommon.

How much does EmbryoGlue cost?
Around €160 per application. It is a self-paid service unless covered by private insurance.

Would you like to know whether EmbryoGlue might improve your IVF chances?

We’re here to help. At Kinderwunschzentrum Dresden, we combine empathy with scientific excellence to create your personalized treatment plan.

👉 Book a consultation online via Doctolib – easy, confidential, and convenient.