CatSper Test: Advanced Sperm Function Testing in Male Fertility

When a semen analysis is normal – but pregnancy still doesn’t happen

Unexplained infertility can be deeply frustrating – especially when standard diagnostics such as semen analysis (spermiogram) come back with normal results. For some couples, the missing piece of the puzzle lies not in sperm quantity or appearance, but in sperm function.

The CatSper test (short for Cation Channel of Sperm) evaluates whether sperm cells are truly capable of fertilising an egg. At Kinderwunschzentrum Dresden, we offer this advanced diagnostic test to help uncover hidden male fertility factors and guide more precise treatment planning.

What is the CatSper Test?

If semen analysis is normal but fertilization still does not occur

Sperm cells require more than just motility to fertilise an egg. They rely on special calcium ion channels – known as CatSper channels – to undergo a process called hyperactivation, essential for penetrating the egg’s protective layers.

The CatSper test uses specialised reagents (e.g. CATflux® by Truion) to determine whether these ion channels function correctly. If not, the sperm may reach the egg but fail to fertilise it – a condition undetectable in routine semen analysis.

📌 Studies suggest that 1 in 100 men with unexplained infertility and normal semen parameters may have a CatSper defect. In these cases, ICSI is typically the only effective fertility method.

When is the CatSper Test Recommended?

The CatSper test is especially useful in the following cases:

• Persistent infertility despite normal semen parameters
• Helping to avoid unsuccessful IVF and insemination attempts
• Suspected functional sperm defects (idiopathic infertility)

It provides functional insight into male fertility – not just numbers or morphology.

🔬 How Does the CatSper Test Work?

The procedure is simple and minimally invasive:

1. Sperm sample collection – performed at the clinic or, if needed, at home
2. Specialised lab testing – using diagnostic reagents to assess calcium channel activity
3. Results – typically available within a few hours

The test does not require hormonal stimulation or repeat sampling.

📈 How Reliable is the CatSper Test?

While not yet part of standard fertility diagnostics, the CatSper test offers:

• ✔ Functional data on sperm ability to trigger fertilisation
• ✔ Insight in idiopathic male infertility
• ✔ Potential to avoid ineffective treatments like IUI or IVF when ICSI is the better option

Limitations:

• Performed only in specialised centres
• Requires clinical context for interpretation
• No absolute prediction of treatment success

CatSper Test: Costs & Insurance

As of 2024, the CatSper test is considered a self-pay service.

• Typical cost: €140 (including consultation and report)
• Reimbursement: May be covered by private insurers on request
• Public insurance: Currently not included in standard coverage

Kinderwunschzentrum Dresden will provide a detailed cost estimate tailored to your case.

Where Can You Get the CatSper Test?

Not every clinic offers CatSper diagnostics.Kinderwunschzentrum Dresden is among the few fertility centres in Germany with access to this advanced testing.

• 🧪 Not available for home use
• 🩺 Requires medical consultation and sperm analysis
• 🧬 Genetic counselling may be recommended if results indicate CatSper deficiency

Is the CatSper Test Worth It?

In selected cases, absolutely. Especially:

• The semen analysis appears normal
• To avoid failed IVF/IUI cycles
• To decide whether ICSI is necessary

🎯 The CatSper test is not for everyone. But for the right couple, it can be the key to targeted, effective fertility treatment.

FAQ: CatSper Test Explained

What does the CatSper test check?
It evaluates whether sperm cells have functional calcium ion channels needed to fertilise an egg.

Who should consider this test?
Couples with unexplained infertility, normal sperm results, or failed IVF/IUI attempts.

Is it painful or invasive?
No – it’s based on a standard sperm sample and lab evaluation.

How soon are results available?
Typically within a few hours after sample submission.

Will insurance cover the test?
Public health insurance does not; private insurance may reimburse with prior approval.

Ready to Get Clarity?

Wondering if the CatSper test could provide answers in your fertility journey? Our andrology experts at Kinderwunschzentrum Dresden offer individualised support and diagnostics to help you move forward with confidence.

👉 Schedule a consultation now via Doctolib – online or in person